Endocrine Abstracts

Obesity is associated with hemodynamic alterations that may lead to heart failure (HF), through the development of cardiac structural abnormalities and impairment of ventricular function. Obesity-related neurohormonal and metabolic disturbances may predispose to HF, even in the absence of comorbidities. Excess adipose tissue and in particular visceral adiposity contributes to the altered production of a number of anabolic hormones also involved in the regulation of the cardiac...

Dopamine receptor type 2 (DRD2) represents the main target for pharmacological therapy with dopamine agonists (DAs) in PRL-secreting neuroendocrine pituitary tumors (PRL-PitNET), even if about 10% of patients is resistant. A single paper recently described a somatic mutation in the gene encoding splicing factor 3B subunit 1 (SF3B1) in about 20% of patients with PRL-PitNET, that was associated with PRL hypersecretion, increased cell proliferation and invasion and reduced progre...